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:: Leiomyosarcoma (LMS) Defined ::

Leiomyosarcoma (Gr. Leio- =smooth, myo- = muscle, sarcoma = fleshy growth) is a type of sarcoma which is a neoplasm of smooth muscle. (When a uterine neoplasm is benign, it is a leiomyoma.) Smooth muscle cells make up the involuntary muscles, which are found in most parts of the body: in uterus, stomach and intestines, walls of all blood vessels, and skin. It is therefore possible for leiomyosarcomas to appear at any site in the body. It is however most commonly found in the stomach, small intestine and retroperitoneum.

Leiomyosarcoma is a very rare cancer. It makes up 5-10% of soft tissue sarcomas, which are in themselves rare cancers.

:: About Leiomyosarcoma ::

Leiomyosarcoma is a form of cancer that affects the smooth muscle of the body. It spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body.

LMS is a type of sarcoma which is a neoplasm of smooth muscle. Smooth muscle cells make up the involuntary muscles, which are found in most parts of the body: in the uterus, stomach and intestines, walls of all blood vessels, and skin.

Leiomyosarcoma is a very rare cancer. It makes up 7% of soft tissue sarcomas; in all, LMS affects 4 out of 1,000,000 people.

Presently there is no cure. Remission can be attained, but this rare cancer can reappear at any time. Because of its rarity, few doctors know how to treat it and it attracts very little research.

Tuesday, June 2, 2009

Data on gastrointestinal stromal tumors described by D. Pasku et al

http://www.webpathology.com/slides/slides/Ext.Genitalia_SpermaticCordLMSGross.jpg
Leiomyosarcoma of Spermatic Cord

This was a 4.0 cm leiomyosarcoma arising in the spermatic cord of a 61 year old man. Paratesticular leiomyosarcoma is an extremely rare neoplasm. For a recent review of this tumor, refer to: Fisher C et al. Am J Surg Pathol 2001 Sep; 25(9):1143-9.

According to a study from Greece, "The location of gastrointestinal stromal tumors (GIST) outside of the gastrointestinal system is a rare event. Case presentation: A 56-year old woman presented with a GIST of the pelvis was misdiagnosed and treated as a uterine leiomyosarcoma."

"The diagnosis was made after the CD117 (KIT) positivity in the biopsy of the excised bowel mass four years from the first presentation. During this period she presented a bilateral muscle and subcutaneous metastasis in the gluteal area. The correct diagnosis of the extra-gastrointestinal stromal tumor is a challenge even for experienced pathologists. CD117 (KIT)...
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