Uterine sarcomas in Norway. A histopathological and prognostic survey
of a total population from 1970 to 2000 including 419 patients.
Histopathology. 2009 Feb;54(3):355-64.
Abeler VM, Røyne O, Thoresen S, Danielsen HE, Nesland JM, Kristensen GB.
Division of Pathology, Radiumhospitalet, University Hospital, Oslo,
Norway. vera.maria.abeler@...
AIMS: To determine the frequency and survival of the various types of
uterine sarcoma in the total population of Norway and evaluate
histopathological prognostic factors in order to identify risk groups.
METHODS AND RESULTS: Histopathological review of all uterine sarcoma
cases reported to the Norwegian Cancer Registry during 1970-2000 was
undertaken. Survival dates were provided by The Cancer Registry.
Kaplan-Meier survival curves were generated. The log rank test was
used for univariate analysis and a Cox proportional hazards regression
model for multivariate evaluation of survival. Stage of disease was
the most important prognostic factor for all tumour types.
Tumour size and the mitotic index (MI) were significant prognostic
factors (P < 0.0001) in leiomyosarcomas confined to the uterus and
allowed for separation into three risk groups with marked differences
in prognosis.
The prognosis of endometrial stromal sarcomas confined to the uterus
was related to MI (P < 0.0001) and tumour cell necrosis (P < 0.004).
Combining these parameters allowed for separation into three risk
groups with marked difference in prognosis. In adenosarcomas, tumour
cell necrosis was the only significant prognostic factor.
CONCLUSIONS: There are marked differences in survival between uterine
sarcoma types. Leiomyosarcomas and endometrial stromal sarcomas can be
divided into different groups.
PMID: 19236512
:: LMS Chat ::
:: Leiomyosarcoma (LMS) Defined ::
Leiomyosarcoma (Gr. Leio- =smooth, myo- = muscle, sarcoma = fleshy growth) is a type of sarcoma which is a neoplasm of smooth muscle. (When a uterine neoplasm is benign, it is a leiomyoma.) Smooth muscle cells make up the involuntary muscles, which are found in most parts of the body: in uterus, stomach and intestines, walls of all blood vessels, and skin. It is therefore possible for leiomyosarcomas to appear at any site in the body. It is however most commonly found in the stomach, small intestine and retroperitoneum.
Leiomyosarcoma is a very rare cancer. It makes up 5-10% of soft tissue sarcomas, which are in themselves rare cancers.
:: About Leiomyosarcoma ::
Leiomyosarcoma is a form of cancer that affects the smooth muscle of the body. It spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body.
LMS is a type of sarcoma which is a neoplasm of smooth muscle. Smooth muscle cells make up the involuntary muscles, which are found in most parts of the body: in the uterus, stomach and intestines, walls of all blood vessels, and skin.
Leiomyosarcoma is a very rare cancer. It makes up 7% of soft tissue sarcomas; in all, LMS affects 4 out of 1,000,000 people.
Presently there is no cure. Remission can be attained, but this rare cancer can reappear at any time. Because of its rarity, few doctors know how to treat it and it attracts very little research.
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