2009 JAN 5 -- "Multiple primary malignant neoplasms (MPMN) ore not uncommon, however, finding more than three primary malignancies in one individual is unusual. Surviving five malignancies is considered exceptional," scientists in Rome, Italy report.
"Two patients surviving five primary malignant neoplasms for 12 and 18 years are reported: a 55-year-old woman with a squamous cell carcinoma of the larynx, two carcinomas of the breast, a carcinoma of the kidney and an adenocarcinoma of the colon, and a 75-year-old woman with a sarcoma of the myometrium, a carcinoma of the thyroid, an adenocarcinoma of the rectum a leiomyosarcoma of the colon and a bronchial carcinoid. Only twelve other reported cases with five or more primary infiltrating malignancies involving more than three sites. diagnosed while the patient was alive have been found," wrote M.C. Cercato and colleagues.
The researchers concluded: "Relevant features were that colon cancer was quite often present more than once and survival was longer than expected for the stage (median overall survival, 20 Years: 95% confidence interval: 12-28 years)."
Cercato and colleagues published their study in Anticancer Research (Report of Two Cases of Quintuple Primary Malignancies and Review of the Literature. Anticancer Research, 2008;28(5B):2953-2958).
For additional information, contact M.C. Cercato, Italian National Cancer Institute Regina Elena, Dept. of Epidemiology, Via Elio Chianesi 53, I-00144 Rome, Italy.
The publisher's contact information for the journal Anticancer Research is: International Institute Anticancer Research, Editorial Office 1ST km Kapandritiou-Kalamou Rd. Kapandriti, PO Box 22, Athens 19014, Greece.
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