New findings from Mayo Clinic describe advances in leiomyosarcoma

2009 APR 20 -- According to recent research from the United States, "Inferior vena cava (IVC) leiomyosarcoma is a rare tumor of smooth muscle origin. It is often large by the time of diagnosis and may involve adjacent organs."

"A margin-free resection may be curative, but the resection must involve the tumor en bloc with the affected segment of vena cava and locally involved organs. IVC resection often requires vascular reconstruction, which can be done with prosthetic graft. Case presentation: We describe a 39-year-old man with an IVC leiomyosarcoma that involved the adrenal gland, distal pancreas, and blood supply to the spleen and left kidney.

Study findings on leiomyosarcoma are outlined in reports from University of Vienna, Medical Department

2009 JAN 5 -- "Uterine leiomyosarcoma during pregnancy is an extremely rare event. The incidence of meningioma during pregnancy is comparable with that in nonpregnant women of the same age group," investigators in Vienna, Austria report.

"We report a case of both - a primary uterine leiomyosarcoma and additionally all atypical meningioma of the brain both diagnosed during pregnancy. The patient was admitted with generalised seizures at 31 weeks of gestation. A tumoural mass was detected and initial conservative treatment was started. The patient delivered her infant via caesarean section, at 34 weeks of gestation. During caesarean section a pedunculated uterine fibroid was removed and total gross resection due to the brain tumour was also performed. Histopathological diagnosis of both tumours revealed an atypical meningioma of the brain and a uterine leiomyosarcoma. The patient underwent laparatomy and received six cycles of adjuvant chemotherapy. We are the first to report a case of a woman with two separate primary neoplasms both diagnosed during pregnancy," wrote B. Bodneradler and colleagues, University of Vienna, Medical Department.

The researchers concluded: "Treatment options seem to be reduced in pregnant women and mainly depend on the patient's condition as well as the gestational age at presentation."

Bodneradler and colleagues published their study in Anticancer Research (Primary Uterine Leiomyosarcoma and Primary Atypical Meningioma Diagnosed during Pregnancy. Anticancer Research, 2008;28(5B):3083-3085).

For additional information, contact B. Bodneradler, University of Vienna, School Medical, Dept. of Obstetrics & Gynecology, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.

The publisher of the journal Anticancer Research can be contacted at: International Institute Anticancer Research, Editorial Office 1ST km Kapandritiou-Kalamou Rd. Kapandriti, PO Box 22, Athens 19014, Greece.

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New findings from M.C. Cercato and co-authors in the area of carcinoma published

2009 JAN 5 -- "Multiple primary malignant neoplasms (MPMN) ore not uncommon, however, finding more than three primary malignancies in one individual is unusual. Surviving five malignancies is considered exceptional," scientists in Rome, Italy report.

"Two patients surviving five primary malignant neoplasms for 12 and 18 years are reported: a 55-year-old woman with a squamous cell carcinoma of the larynx, two carcinomas of the breast, a carcinoma of the kidney and an adenocarcinoma of the colon, and a 75-year-old woman with a sarcoma of the myometrium, a carcinoma of the thyroid, an adenocarcinoma of the rectum a leiomyosarcoma of the colon and a bronchial carcinoid. Only twelve other reported cases with five or more primary infiltrating malignancies involving more than three sites. diagnosed while the patient was alive have been found," wrote M.C. Cercato and colleagues.

The researchers concluded: "Relevant features were that colon cancer was quite often present more than once and survival was longer than expected for the stage (median overall survival, 20 Years: 95% confidence interval: 12-28 years)."

Cercato and colleagues published their study in Anticancer Research (Report of Two Cases of Quintuple Primary Malignancies and Review of the Literature. Anticancer Research, 2008;28(5B):2953-2958).

For additional information, contact M.C. Cercato, Italian National Cancer Institute Regina Elena, Dept. of Epidemiology, Via Elio Chianesi 53, I-00144 Rome, Italy.

The publisher's contact information for the journal Anticancer Research is: International Institute Anticancer Research, Editorial Office 1ST km Kapandritiou-Kalamou Rd. Kapandriti, PO Box 22, Athens 19014, Greece.

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